Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Season 22 Episode
- Season 7 Kevin James, Sheryl Crow
- Season 7 Ricki Lake, Kid Rock
- Season 7 Craig Kilborn, Louise Smith, The Umbilical Brothers
- Season 7 Queen Latifah, John Popper
- Season 7 John McEnroe, Sharon Lawrence, Nanci Griffith
- Season 7 Kid Scientists, Edie Falco, Dixie Chicks
- Season 7 John Leguizamo, Meat Loaf
- Season 7 Jenna Elfman, Chris Kattan, Christine Aguilera
- Season 7 Heather Locklear, Keyshawn Johnson
- Season 7 Michael J. Fox, Heather French
- Season 7 Robin Williams, Norm MacDonald
- Season 7 Stupid Pet Tricks, Ashley Judd, Randy Travis
- Season 7 Mark Wahlberg, Adam Sandler, Roger Ebert
- Season 7 Kelly Preston, Stirling Moss, Sugar Ray
- Season 7 Kevin Pollak, Tom Waits
- Season 7 Nathan Lane, Emmylou Harris & Linda Rondstadt
- Season 7 Mia Farrow, Russell Crowe, Paula Cole Band
- Season 7 Kevin Spacey, Eurythmics
- Season 7 Kelsey Grammer, Rebecca Gayheart
- Season 7 Harrison Ford, David Bowie
- Season 7 Dan Quayle, Melissa Ethridge
- Season 7 Lili Tomlin, Leah Remini, Beth Hart
- Season 7 Jesse Ventura, Amy Brennamen, ZZ Top
- Season 7 Jack Hanna, Peter Fonda, Sting
- Season 7 Bruce Willis, Will Ferrell
- Season 7 Chazz Palminteri, Billy Blanks, Wilson Pickett
- Season 7 Farrah Fawcett
- Season 7 John Malkovich, Harland Williams
- Season 7 Austin Payne, Patricia Arquette, Moby
- Season 7 Charles Grodin, Jimmie Walker, Buena Vista Social Club
- Season 7 John Cusack, Bob Sarlatte, LeAnn Rimes
- Season 7 Martha Stewart, Martin Scorcese, Ricky Martin
- Season 7 Joe Torre, Denzel Washington
- Season 7 Meryl Streep, Natalie Merchant
- Season 7 Luke Perry, Jimmy Kimmel, Garbage
- Season 7 Lauren Holly, Jimmy Fallon, Rage Against the Machine
- Season 7 Bill Cosby, Milla Jovovich
- Season 7 Susan Sarandon, Juan Montoya, East Harlem Violinists
- Season 7 Regis Philbin, Mitch Hedberg
- Season 7 Woody Harrelson, Bobby Rahal
- Season 7 Don Rickles, Jane Clayson
- Season 7 Jack Hanna, Bob Hoskins, Melanie C
- Season 7 Natalie Portman, Travis Pastrana, Ted Alexandro
- Season 7 Stupid Human Tricks, Johnny Depp
- Season 7 Claudia Schiffer, Chris Cornell
- Season 7 Will Smith, Creed
- Season 7 Anthony Edwards, Yasmine Bleeth
- Season 7 Evander Holyfield, Ted Danson, Counting Crows
- Season 7 Gabriel Byrne, Mark Borchardt
- Season 7 Bryant Gumbel, John Carpenter, Tony Bennett
- Season 7 Kathie Lee Gifford, Charlotte Church
- Season 7 Julianna Margulies, Eric Ripert, Third Eye Blind
- Season 7 George Carlin, Jewel
- Season 7 Stupid Pet Tricks, William Baldwin
- Season 7 Barbara Walter, Dan Patrick, Mary J. Blige
- Season 7 Jenny McCarthy, Martha Stewart, Foo Fighters
- Season 7 Tim Robbins, Laetitia Casta, B.B. King & Dr. John
- Season 7 Patrick Stewart, Al Franken, Bob Marley
- Season 7 Geena Davis, Bill Murray, Fiona Apple
- Season 7 Courtney Love, Tori Murden, R.E.M.
- Season 7 Gwyneth Paltrow, Blondie
- Season 7 Danny DeVito, Harry Smith
- Season 7 Jim Carrey, Alanis Morrisette
- Season 7 Joe Breen, Jude Law
- Season 7 Tom Brokaw, Alex Kingston, Run DMC
- Season 7 Emily Watson, LL Cool J
- Season 7 Marv Albert, Heather Matarazzo, Bruce Henderson
- Season 7 Hallie Eisenberg, Jon Witherspoon, Darlene Love
- Season 7 Matt Damon, Q-Tip
- Season 7 Isabella Rossellini, Bev Tanner
- Season 7 Jay Thomas, Nick Nordberg
- Season 7 Dick Clark, Ralph Charles
- Season 7 Stupid Human Tricks, Kevin James, Brooklyn Philharmonic
- Season 7 Jeff Daniels, Jake Johannsen
- Season 7 Lauren Bacall, Kurt Warner
- Season 7 Bill Pullman, Dan Naturman
- Season 7 George Stephanopoulos, Sue Murphy
- Season 7 Edie Falco, Ray Lucas, Andy Kindler
- Season 7 Kate Winslet, Ice Cube
- Season 7 Woody Harrelson, Shawn Presser, Filter
- Season 7 Hillary Clinton, Art Donovan
- Season 7 Tom Arnold, Art Donovan, Lynryd Skynryd
- Season 7 Regis Philbin, Mark Borchardt
- Season 7 Charles Grodin, Julia Roberts, Regis Philbin
- Season 7 Regis Philbin, Jerry Seinfeld, Danny DeVito
- Season 7 Paul Schaffer, Bruce Willis, Martin Short
- Season 7 Regis Philbin, Bill Cosby, Sarah Jessica Parker
- Season 7 Paul Schaffer, Steve Martin, Billy Crystal
- Season 7 Paul Schaffer, Drew Barrymore, Ray Romano
- Season 7 David Brenner, Kathie Lee Gifford, Alec Baldwin
- Season 7 Tom Snyder, Norm MacDonald, Don Rickles
- Season 7 Tom Snyder, Mike Myers, Roseanne, Bonnie Hunt
- Season 7 Tom Arnold, Robin Williams, Jack Hannah
- Season 7 Regis Philbin, Robin Williams, Foo Fighters
- Season 7 Bill Cosby, Heidi Klum, Vince Carter, Dr. Paula Mahone, Dane Cook
- Season 7 Julia Roberts, Israel Perlman
- Season 7 Kathie Lee Gifford, Tom Arnold, Joy Behar, Linda Edar
- Season 7 John Goodman, Norm MacDonald
- Season 7 Drew Carey, Dolly Parton
- Season 7 David Brenner, Carson Daley, Aida Turturro, Gary Gulman, Ben Harper & The Innocent Criminals
- Season 7 Kid Turkey Callers, Candice Bergan, Fiona Apple, George W. Bush
- Season 7 Nathan Lane, Mel Brooks, Mario Cantone, Kristin Chenoweth
- Season 7 Anjelica Huston, Jayson Williams, Steely Dan
- Season 7 Kathie Lee Gifford, Eddie Izzard
- Season 7 Janeane Garofalo, Bob Odenkirk & David Cross, Zack Galifanakis, Old '97s
- Season 7 Tim Robbins, Melissa Etheridge
- Season 7 Dana Carvey, Jon Lovitz, Cindy Margolis, Al Frankin, Rocco DiSpirito
- Season 7 Tom Brokaw, Catherine Keener, Bonnie Raitt
- Season 7 Gabriel Byrne, Martha Stewart, Moby
- Season 7 Matthew Broderick, Patti Smith
- Season 7 Barbara Walters, Linda Cardellini, Kimmie Rhodes
- Season 7 Rosie Perez, Robert Klein
- Season 7 Minnie Driver, Trisha Yearwood
- Season 7 Kid Scientists, Jimmy Smits, Bruce Cockburn
- Season 7 John Cusack, Paul Fiora, Eddie Brill
- Season 7 David Arquette, Al Green
- Season 7 Brooke Shields, Oliver Platt, Joni Mitchell
- Season 7 David Duchovny, Joe Pistone, Lou Reed
- Season 7 Bonnie Hunt, Shelby Lynne
- Season 7 Samuel L. Jackson, Jack Hannah
- Season 7 Jon Stewart, Faith Hill
- Season 7 Bill Cosby, Sarah Vowell
- Season 7 Jenna Elfman, Jeff Altman, Children of Uganda
- Season 7 Paul Newman, Pearl Jam
- Season 7 Matthew McConaughey, Kelly Monteith, Willie Nelson
- Season 7 Ben Stiller, Brian Regan
- Season 7 Jeff Foxworthy, Vertical Horizon
- Season 7 Kristin Johnson, Live
- Season 7 Dennis Quaid, Nicole Sullivan, Smashing Pumpkins
- Season 7 Salma Hayek, Ray Romano
- Season 7 Natalie Portman, Lennox Lewis
- Season 7 David Spade, Marion Jones
- Season 7 Kim Basinger, Oasis
- Season 7 Dana Carvey, Alison Krauss & Union Station
- Season 7 Julia Louis-Dreyfus, Mitch Hedberg
- Season 7 Stupid Human Tricks, Joaquin Phoenix, Mighty Mighty Bosstones
- Season 7 Betty White, Hanson
- Season 7 John Travolta, Cast of Kiss me Kate
- Season 7 Kelsey Grammer, Caroline Rhea
- Season 7 Kathie Lee Gifford, Debra Messing
- Season 7 Richard Simmons, Sarah Vowell
- Season 7 Gillian Anderson, Foo Fighters
- Season 7 David Hyde Pierce, Phish
- Season 7 Hugh Grant, Carly Simon
- Season 7 Jackie Chan, Jim Gaffigan
- Season 7 Ringo Starr, Jane Krakowski
- Season 7 Michael J. Fox, Richard Harris
- Season 7 Earvin 'Magic' Johnson, matchbox 20
- Season 7 Nathan Lane, Gloria Estefan
- Season 7 Sarah Jessica Parker, Penn & Teller
- Season 7 Dan Patrick, Owen Wilson, B.B. King
- Season 7 Alicia Silverstone, David Brenner
- Season 7 Lisa Kudrow, Tom Dreesen, Steve Earle and the Dukes
- Season 7 Robert Duvall, Don Henley
- Season 7 Roger Ebert, Nia Long
- Season 7 Martin Lawrence, Sinead O'Connor
- Season 7 Jimmy Connors, David Coulthard
- Season 7 Marv Albert, Heath Ledger, Bon Jovi
- Season 7 Calista Flockhart, Isaac Hayes
- Season 7 Naomi Campbell, Juan Montoya
- Season 7 Stupid Pet Tricks, Jimmy Kimmel, Billy Bragg & Wilco
- Season 7 John McEnroe, Busta Rhymes
- Season 7 Mark Wahlberg, The Deftones
- Season 7 Dana Carvey, No Doubt
- Season 7 Samuel L. Jackson, P.J. Ollson
- Season 7 Piedmont Bird Callers, Keenan Ivory Wayans
- Season 7 Tom Brokaw, Eric Idle
- Season 7 James Belushi, Third Eye Blind
- Season 7 Martha Stewart, Travis
- Season 7 George Clooney, Warren Zevon
- Season 7 Jay Thomas, David Sedaris
- Season 7 Tom Arnold, Brian Wilson
- Season 7 National Hollerin' Champions, Skye McCole Bartusiak
- Season 7 Ellen Degeneres, Sheryl Crow & Steve Earle
- Season 7 Daljit Dhaliwal, Shawn Wayans
- Season 7 Jason Alexander, Tracy Chapman
- Season 7 Bruce Willis, Elliot Smith
- Season 7 Marilu Henner, Dixie Chicks
- Season 7 Will Ferrell, Ben Folds Five
- Season 7 Jeff Daniels, Bob Sarlatte
- Season 7 Jon Stewart, Lucy Pearl
- Season 7 Harrison Ford
- Season 7 Don Rickles, Ween
- Season 7 Kathie Lee Gifford, Bev Tanner
- Season 7 Connie Chung, Harry Hill
- Season 7 Roseanne, David Gray
- Season 7 Edie Falco, Macy Gray
- Season 7 Nathan Lane, John Pizzarelli Trio
- Season 7 Joy Philbin, Joe Lockhart
- Season 7 Al Roker, Craig Ferguson
- Season 7 Darrell Hammond, Todd Rundgren
- Season 7 Tom Selleck, Jordan
- Season 7 Al Franken, Guster
- Season 7 Sam Donaldson, Kid Rock
- Season 7 Jennifer Lopez, Reggie Jones
- Season 7 Vince Vaughn, Eels
Late Show with David Letterman - Season 7 Episode 105 Janeane Garofalo, Bob Odenkirk & David Cross, Zack Galifanakis, Old '97s
6.34 63 minutes Janeane Garofalo becomes the latest guest host; ""slide whistle legend"" Bazeel sits in; Janeane does tonight's interviews sitting in a school desk placed in front of Dave's desk; Bob Odenkirk and David Cross make funny noises; Bazeel and the band performs ""Wipe Out.""
