Season
- Season 1 1993-08-30
- Season 2 1994-08-29
- Season 3 1995-09-04
- Season 4 1996-09-02
- Season 5 1997-09-01
- Season 6 1998-08-31
- Season 7 1999-09-07
- Season 8 2000-08-21
- Season 9 2001-08-20
- Season 10 2002-09-03
- Season 11 2003-09-01
- Season 12 2004-08-23
- Season 13 2005-08-29
- Season 14 2006-08-28
- Season 15 2007-09-04
- Season 16 2008-09-02
- Season 17 2009-08-31
- Season 18 2011-01-03
- Season 19 2012-01-03
- Season 20 2013-01-02
- Season 21 2014-01-06
- Season 22 2014-09-02
Season 22 Episode
- Season 18 Brian Williams, Paula Abdul
- Season 18 Tim McGraw, Shaquille O'Neal, Keri Hilson
- Season 18 Jennifer Connelly, Dr. Oz, Justin Townes Earle
- Season 18 Seth Rogen, Beau Garrett, the Walkmen
- Season 18 Regis Philbin, Hannibal Buress, No Age
- Season 18 Bill Cosby, a Top Ten List presented by Nicole "Snooki" Polizzi, the Black Keys
- Season 18 Vince Vaughn, Mike Wolfe & Frank Fritz, Cage the Elephant
- Season 18 Kevin James, Olivia Munn, The Low Anthem
- Season 18 Kelsey Grammer, Amar'e Stoudemire, Gregg Allman
- Season 18 Joan Rivers, Jeff Caldwell, Wintersleep
- Season 18 Jack Hanna, Steven Tyler
- Season 18 Betty White, Kim & Kourtney Kardashian, the Script
- Season 18 Martin Short, Greta Gerwig, Darius Rucker
- Season 18 Kaley Cuoco, Piers Morgan, Wanda Jackson, Miss Arkansas, Alyse Eady
- Season 18 Nathan Lane, Mike Palascak, Esperanza Spalding
- Season 18 Justin Bieber, Pauley Perrette, Best Coast
- Season 18 Matthew Perry, Chris Elliott, Top Ten with Mitt Romney, the National
- Season 18 Kate Walsh, Jim Gaffigan, Boxer Rebellion
- Season 18 Howard Stern, Naughty By Nature
- Season 18 Martha Stewart, Top Ten with Justin Bieber, Robert Plant
- Season 18 Super Bowl MVP Aaron Rodgers, Martin Lawrence, Steel Magnolia
- Season 18 Adam Sandler, Chris Colfer, Gang of Four
- Season 18 Anderson Cooper, Elton John
- Season 18 Nicole "Snooki" Polizzi, Judah Friedlander, Bryan Ferry
- Season 18 Ed Helms, Ted Alexandro, Steel Magnolia
- Season 18 S.I. Swimsuit Cover Reveal & Top 10, Tom Brokaw, Theophilus London
- Season 18 Forest Whitaker, S.I. Swimsuit Cover Model Irina, Josh Groban, Top Ten with Joy Philbin
- Season 18 Bill Hader, Grocery Bagging Champ Krystal, Amos Lee
- Season 18 Paris Hilton, Nathan Fillion, Scissor Sisters
- Season 18 David Spade, Andy Kindler, Lukas Nelson and Promise of the Real
- Season 18 Donald Rumsfeld, Cobie Smulders
- Season 18 Amy Poehler, Jean Chu and Dusty the Cat, Deerhunter
- Season 18 Rainn Wilson, Hank Aaron
- Season 18 Senator Rand Paul, Bright Eyes
- Season 18 Matthew Morrison, Jeff Altman, Jessica Lea Mayfield
- Season 18 Brian Williams, Trey Parker & Matt Stone, Zac Brown Band
- Season 18 Amanda Seyfried, B.J. Novak
- Season 18 Donald Trump, Vanessa Hudgens, Oh Land
- Season 18 Robin Williams, Judy Greer
- Season 18 Charles Barkley, Sarah Vowell, Cold War Kids
- Season 18 Bradley Cooper, Mindy Kaling, Bob Geldof
- Season 18 Steve Martin, Selena Gomez
- Season 18 Dana Carvey, Dr. Michio Kaku, British Sea Power
- Season 18 Katie Couric, The Pains of Being Pure at Heart
- Season 18 Ben Stiller, Dario Franchitti, The Strokes
- Season 18 "Jungle" Jack Hanna, Danny McBride
- Season 18 Regis Philbin, Snoop Dogg
- Season 18 Norm Macdonald, CC Sabathia, Willie Nelson, Norah Jones and Wynton Marsalis
- Season 18 Chris Rock, Ellen Page, Funeral Party
- Season 18 James Franco, Royal Bangs
- Season 18 Jennifer Garner, Jamie Oliver, Robbie Robertson
- Season 18 Don Rickles, Eva Longoria
- Season 18 Alec Baldwin, Wiz Khalifa
- Season 18 Ricky Gervais, Top Ten with Katie Holmes, Foo Fighters
- Season 18 Courteney Cox, Aziz Ansari, Alison Krauss & Union Station featuring Jerry Douglas
- Season 18 Seth Meyers, Carmelo Anthony, TV on the Radio
- Season 18 Tina Fey, Tommy Johnagin, The Gaslight Anthem
- Season 18 Bill Maher, Cote de Pablo, Lupe Fiasco
- Season 18 Will Ferrell, The Twilight Singers
- Season 18 Kate Hudson, Rich Eisen, Emmylou Harris
- Season 18 Dr. Phil McGraw, Chris Hemsworth, Broadway musical "Catch Me If You Can"
- Season 18 John Krasinski, Brian Kiley, Steve Earle
- Season 18 Brian Williams, Rex Ryan
- Season 18 Caroline Kennedy, Ty Burrell
- Season 18 Betty White, Rick Harrison, Morning Teleportation
- Season 18 Jodie Foster, Tom Dreesen, Neon Trees
- Season 18 Bill Murray, ''The Human Fuse'' Brian Miser, Brother
- Season 18 Albert Brooks, Kristen Wiig
- Season 18 Mark Harmon, Chris Morgan, Hugo
- Season 18 Stupid human tricks, Jim Parsons, Manchester Orchestra
- Season 18 Joan Rivers, Nick Griffin, Okkervil River
- Season 18 Julianna Margulies, Andy Cohen, a Top Ten List presented by Christina Aguilera, White Lies
- Season 18 Martin Short, Melissa McCarthy, Tinie Tempah
- Season 18 Keith Olbermann, Julie Bowen, Ben Harper
- Season 18 Kelly Ripa, Jennifer Lawrence, How to Succeed in Business Without Really Trying
- Season 18 Tracy Morgan, Jake Johannsen, The Airborne Toxic Event
- Season 18 Lady Gaga, Eric Stonestreet, The Vaccines
- Season 18 Ewan McGregor, Scott Pelley, Brad Paisley
- Season 18 Piedmont Bird Callers, Kevin Bacon, Augustana
- Season 18 Ray Romano, Reese Waters, Arctic Monkeys
- Season 18 Meredith Vieira, Indianapolis 500 winner Dan Wheldon, Drum Solo Week kicks off with Anton Fig
- Season 18 Kyle Chandler, Kathy Griffin, Sheila E.
- Season 18 Jon Cryer, Rachel Maddow, Roy Haynes
- Season 18 Neil Patrick Harris, Mike Birbiglia, Neil Peart
- Season 18 Adm. Michael Mullen, Top Ten by Betty White, Black Joe Lewis & the Honeybears
- Season 18 Ryan Reynolds, chef Eric Ripert and the cast of the Broadway musical Anything Goes
- Season 18 Jim Carrey, Rosie Huntington-Whiteley, Todd Rundgren
- Season 18 Samuel L. Jackson, Texas Ranger Josh Hamilton, Jennifer Hudson
- Season 18 Cameron Diaz, Eddie Vedder
- Season 18 Jason Bateman, Amy Sedaris, Top Ten by Keith Olbermann, Drive-By Truckers
- Season 18 Kevin James, pet fashion designer Ada Nieves, Beady Eye
- Season 18 Jason Segel, horse whisperer Buck Brannaman, Noah and the Whale
- Season 18 Shia LaBeouf, Bert Kreischer, Dawes
- Season 18 Tom Hanks, Sleepy Man Banjo Boys
- Season 18 Patrick Dempsey, Erica Hill, Marty Stuart
- Season 18 Julia Roberts, Cake
- Season 18 Emma Watson, George Lopez, Incubus
- Season 18 Roseanne Barr, Tom Felton, Blake Shelton
- Season 18 Ryan Gosling, Gomez
- Season 18 Kyra Sedgwick, Tim Harmston, Nikki Jean
- Season 18 Bono & the Edge, a performance from Spider-Man: Turn Off the Dark
- Season 18 Steve Carell, Hope Solo and Abby Wambach, The Del McCoury Band and the Preservation Hall Band
- Season 18 Jeremy Piven, Captain Luis Montalvan, Cee-Lo Green
- Season 18 Harrison Ford, Porcelain Black
- Season 18 Brian Williams, Tim Robbins & the Rogues Gallery Band
- Season 18 Julianne Moore, Johnny Galecki, Tanner Foust, Eels
- Season 18 Craig Ferguson, Connie Britton, Anna Calvi
- Season 18 Kirstie Alley, Louis C.K., Fountains of Wayne
- Season 18 James Franco, Dianna Agron, Christina Perri
- Season 18 Ricky Gervais, Cat Deeley, Explosions in the Sky
- Season 18 Emma Stone, Alan Mulally, Sallie Ford
- Season 18 Colin Farrell, Christopher Ferguson, Typhoon
- Season 18 Denis Leary, Elizabeth Cook, Drum Solo Week II kicks off with Tony Royster Jr.
- Season 18 Rachel Maddow, Rose Byrne, Gavin Harrison
- Season 18 Ashton Kutcher, Rafael Nadal, Stewart Copeland
- Season 18 Paul Rudd, Bill Burr, Dennis Chambers
- Season 18 Jason Sudeikis, Bettina Luescher, St. Vincent
- Season 18 Alec Baldwin, Joe Namath, Lenny Kravitz
- Season 18 David Arquette, Aubrey Plaza, Thurston Moore
- Season 18 Julianna Margulies, Joe Wong, Lady Antebellum
- Season 18 Kim, Kourtney & Khloe Kardashian, Michael Emerson, The Jim Jones Revue
- Season 18 Sgt. 1st Class Leroy Petry, Sarah Jessica Parker
- Season 18 Michael J. Fox, Top Ten by the cast of Two and a Half Men, Jim McDonald, John Doe
- Season 18 Dr. Jill Biden, Ted Danson
- Season 18 Jonah Hill, Paula Abdul, Coldplay
- Season 18 Taylor Lautner, Minka Kelly, Wilco
- Season 18 Sergeant Dakota Meyer, Sofia Vergara, Chris Cornell
- Season 18 Nathan Fillion, Larry Miller, The Jayhawks
- Season 18 Seth Rogen, Poppy Montgomery, Fleet Foxes
- Season 18 Jack Hanna, Anna Faris
- Season 18 Anderson Cooper, Nick Offerman, The Knux
- Season 18 Kaley Cuoco, Skipper Bivins & Trent Jackson, Death Cab for Cutie
- Season 18 Samuel L. Jackson, Karen Rontowski, Anne-Sophie Mutter
- Season 18 Brian Williams, Sting
- Season 18 Hugh Jackman, Sean Young, Feist
- Season 18 George Clooney, Mastodon
- Season 18 Caroline Kennedy, dock diving dogs, The Joy Formidable
- Season 18 Bryan Cranston, Jeff Altman, Garland Jeffreys
- Season 18 Tracy Morgan, Mike Golic & Mike Greenburg, Mates of State
- Season 18 Matthew Broderick, horse wrangler Erin Bolster and her horse Tonk, Hunter Hayes
- Season 18 Bill Clinton, Deer Tick
- Season 18 Bill O'Reilly, Martina McBride
- Season 18 Artie Lange, Eddie Brill, Beirut
- Season 18 Salma Hayek, Keith Olbermann, Jane's Addiction
- Season 18 Eddie Murphy, Jane Levy, Mayer Hawthorne
- Season 18 Justin Timberlake, Jennifer Esposito, The Civil Wars
- Season 18 Johnny Depp, Foster the People
- Season 18 Tom Brokaw, Myq Kaplan, The Head & The Heart
- Season 18 Tony La Russa, Jesse Eisenberg, Puscifer
- Season 18 Ben Stiller, Whitney Cummings
- Season 18 Condoleezza Rice
- Season 18 Mark Harmon, Mike Judge, Top Ten by Matt Lauer, Eli Young Band
- Season 18 Bill Cosby, Jason Isbell and The 400 Unit
- Season 18 Melissa McCarthy, Anthony Bourdain, Joan Baez & Kris Kristofferson
- Season 18 Robert Pattinson, Annie Leibovitz, David Crosby and Graham Nash
- Season 18 Adam Sandler, Peter Gabriel
- Season 18 Stupid Humans Tricks, Katie Holmes, Noel Gallagher's High Flying Birds
- Season 18 Steve Martin, Felicity Jones, Lonesome River Band feat. Steve Martin
- Season 18 Jason Segel, Jamie Oliver, The Kooks
- Season 18 Bill Maher, Nikki Reed, Foo Fighters feat. Joan Jet
- Season 18 Jerry Seinfeld, Lykke Li
- Season 18 Regis Philbin, John Fogerty
- Season 18 Herman Cain, Grouplove
- Season 18 Andy Kindler, Ty Burrell, Gayle King, Needtobreathe
- Season 18 Amy Sedaris, Christopher "Mad Dog" Russo, Sondre Lerche
- Season 18 Justin Bieber, Brian Regan, FreeSol
- Season 18 Jonah Hill, Kristen Johnston, Ryan Adams
- Season 18 Matt Damon, Shelby Lynne
- Season 18 Jessica Biel, Tom Dreesen, The Black Keys
- Season 18 Charlize Theron, Kevin Nealon, Blitzen Trapper
- Season 18 David Duchovny, Comedian Hugh Fink, Young Jeezy
- Season 18 Scarlett Johansson, Julie Chen, Top Ten by the 2011 Heisman Trophy winner Robert Griffin III
- Season 18 Barbara Walters, Bill Hader, Wild Flag
- Season 18 Robert Downey Jr., Rooney Mara
- Season 18 Tom Hanks, My Morning Jacket
- Season 18 Jude Law, Bob Sarlatte, Gary Clark Jr.
- Season 18 Tom Cruise, Anthony Hamilton, Top Ten by Mitt Romney
- Season 18 Harry Connick Jr., Scott Van Pelt, Mariachi El Bronx
- Season 18 Jon Huntsman, J. Cole
- Season 18 Anderson Cooper, Lindsey Vonn, Childish Gambino
- Season 18 Jay Thomas, David Hyde Pierce, Darlene Love
Late Show with David Letterman - Season 18 Episode 162 Jerry Seinfeld, Lykke Li
6.30 63 minutes Dave welcomes comedian Jerry Seinfeld and musical guest Lykke Li.
